On April 16, 2011, a 32-year-old Orlando Salido (35-11-2, 23 KOs) got a shot at the WBO featherweight title held by 27-year-old Puerto Rican boxer Juan Manuel López (30-0, 27 KOs).
Salido came in to the fight on a 1-fight losing streak with a 47% KO rate, and was fighting after a gap of 7 months and 5 days. López was on a 30-fight win streak with a 90% KO rate, and fighting after a layoff of 5 months and 10 days.
Orlando Salido stopped the champion via TKO in the 8th round of the 12-round world-title fight, and is crowned the new WBO featherweight champion. Salido improves his record to 36-11-2 (24 KOs), while López adds a loss to his record at 30-1.
On March 10, 2012, Orlando Salido and Juan Manuel López met again in a rematch.
Salido came in to the fight on a 3-fight win streak with a 51% KO rate, and was fighting after a gap of 2 months and 22 days. López was on a 1-fight win streak with a 87% KO rate, and fighting after a layoff of 5 months and 9 days.
In the rematch, Orlando Salido stopped Juan Manuel López via TKO in the 10th round of the 12-round world-title fight, and successfully defended his WBO featherweight title. Salido improves his record to 39-11-2 (27 KOs), while López adds a loss to his record at 31-2.
On October 12, 2013, 34-year-old Orlando Salido (40-12-2, 28 KOs) and Orlando Cruz fought for the vacant WBO featherweight title.
Salido came in to the fight on a 1-fight losing streak with a 51% KO rate, and was fighting after a gap of 8 months and 23 days.
Orlando Salido stopped Orlando Cruz via TKO in the 7th round of the 12-round world-title fight. Salido improves his record to 41-12-2 (29 KOs)
On May 15, 2010, Orlando Salido and Cristóbal Cruz met again in a rematch.
Salido came in to the fight on a 2-fight win streak with a 50% KO rate, and was fighting after a gap of 9 months and 15 days.
Orlando Salido defeated Cristóbal Cruz via unanimous decision in the rematch and wins the IBF title — in his first world-title fight. Salido improves his record to 35-10-2
On July 23, 2011, the 32-year-old WBO featherweight world champion, Orlando Salido (36-11-2, 24 KOs), faced Kenichi Yamaguchi, in a title defense fight.
Salido came in to the fight on a 1-fight win streak with a 49% KO rate, and was fighting after a gap of 3 months and 7 days.
Orlando Salido stopped Kenichi Yamaguchi via TKO in the 11th round of the 12-round world-title fight, and successfully defended his WBO featherweight title. Salido improves his record to 37-11-2 (25 KOs)
On June 4, 2016, a 37-year-old Orlando Salido (43-13-3, 30 KOs) got a shot at the super-featherweight WBC title held by 31-year-old fellow Mexican boxer Francisco Vargas (23-0-1, 17 KOs).
Salido came in to the fight after a draw in his last fight with a 50% KO rate, and was fighting after a gap of 8 months and 23 days. Vargas was on a 20-fight win streak with a 70% KO rate, and fighting after a layoff of 6 months and 14 days.
The fight ended in a majority decision draw and both the fighters added a draw to their respective records — Salido is now 43-13-4 and Vargas, 23-0-2.
On September 20, 2014, a 35-year-old Orlando Salido (42-12-2, 29 KOs) and Terdsak Kokietgym met in the ring in a super-featherweight bout.
Salido came in to the fight on a 2-fight win streak with a 51% KO rate, and was fighting after a gap of 6 months and 19 days.
Orlando Salido stopped Terdsak Kokietgym via KO in the 11th round. Salido improves his record to 43-12-2 (30 KOs)
On March 1, 2014, 35-year-old Orlando Salido (41-12-2, 29 KOs) and 26-year-old Vasyl Lomachenko (1-0, 1 KO) fought for the vacant WBO featherweight title.
Salido came in to the fight on a 1-fight win streak with a 52% KO rate, and was fighting after a gap of 4 months and 17 days. Lomachenko was on a 1-fight win streak with a 100% KO rate, and fighting after a layoff of 4 months and 17 days.
Orlando Salido defeated Vasyl Lomachenko via split decision . Salido improves his record to 42-12-2, while Lomachenko adds a loss to his record at 1-1.
On September 12, 2015, Orlando Salido and Román Martínez met again in an immediate rematch.
Salido came in to the fight on a 1-fight losing streak with a 51% KO rate, and was fighting after a gap of 5 months and 1 day. Martínez was on a 2-fight win streak with a 51% KO rate, and fighting after a layoff of 5 months and 1 day.
The fight ended in a split decision draw and both the fighters added a draw to their respective records — Salido is now 43-13-3 and Martínez, 29-2-3.
On September 11, 2010, a 31-year-old Orlando Salido (35-10-2, 23 KOs) got a shot at the featherweight WBA (Super) title held by 28-year-old Cuban boxer Yuriorkis Gamboa (18-0, 15 KOs).
Salido came in to the fight on a 3-fight win streak with a 48% KO rate, and was fighting after a gap of 3 months and 27 days. Gamboa was on a 18-fight win streak with a 83% KO rate, and fighting after a layoff of 5 months and 15 days.
Yuriorkis Gamboa defeated Orlando Salido via unanimous decision and successfully defended his WBA (Unified) featherweight title. Gamboa improves his record to 19-0, while Salido adds a loss to his record at 35-11-2.