On September 28, 2018, a 22-year-old Alexandro Santiago (16-2-4, 7 KOs) got a shot at the super-flyweight IBF title held by 26-year-old Filipino boxer Jerwin Ancajas (30-1-1, 20 KOs).
Santiago came in to the fight after a draw in his last fight with a 31% KO rate, and was fighting after a gap of 6 months and 4 days. Ancajas was on a 17-fight win streak with a 62% KO rate, and fighting after a layoff of 4 months and 2 days.
The fight ended in a split decision draw and both the fighters added a draw to their respective records — Santiago is now 16-2-5 and Ancajas, 30-1-2.
On July 29, 2023, 27-year-old Alexandro Santiago (27-3-5, 14 KOs) and 40-year-old Nonito Donaire (42-7, 28 KOs) fought for the vacant WBC bantamweight title.
Santiago came in to the fight on a 3-fight win streak with a 40% KO rate, and was fighting after a gap of 9 months. Donaire was on a -1-fight win streak with a 57% KO rate, and fighting after a layoff of 1 year, 1 month, and 22 days.
Alexandro Santiago defeated Nonito Donaire via unanimous decision . Santiago improves his record to 28-3-5, while Donaire adds a loss to his record at 42-8.
On August 10, 2013, a 17-year-old Alexandro Santiago (4-0-1, 3 KOs) and Felix Rubio met in the ring for the 2nd time,.
Santiago came in to the fight on a 1-fight win streak with a 60% KO rate, and was fighting after a gap of 1 month and 13 days.
In the rematch, Alexandro Santiago defeated Felix Rubio via unanimous decision in the 6-round fight. Santiago improves his record to 5-0-1
On October 29, 2022, a 26-year-old Alexandro Santiago (26-3-5, 13 KOs) and a 35-year-old American boxer Antonio Nieves (20-3-2, 11 KOs) met in the ring for the 2nd time,.
Santiago came in to the fight on a 2-fight win streak with a 38% KO rate, and was fighting after a gap of 3 months. Nieves was on a 1-fight win streak with a 44% KO rate, and fighting after a layoff of 1 year, 5 months, and 8 days.
In the rematch, Alexandro Santiago stopped Antonio Nieves via RTD in the 7th round. Santiago improves his record to 27-3-5 (14 KOs), while Nieves adds a loss to his record at 20-4-2.
On February 22, 2019, a 23-year-old Alexandro Santiago (16-2-5, 7 KOs) and Juan Higuera Villanueva met in the ring.
Santiago came in to the fight after a draw in his last fight with a 30% KO rate, and was fighting after a gap of 4 months and 25 days.
Alexandro Santiago stopped Juan Higuera Villanueva via RTD in the 1st round. Santiago improves his record to 17-2-5 (8 KOs)
On September 24, 2016, a 20-year-old Alexandro Santiago (11-2-2, 3 KOs) and Luis Lozano met in the ring.
Santiago came in to the fight after a draw in his last fight with a 20% KO rate, and was fighting after a gap of 1 month and 5 days.
Alexandro Santiago stopped Luis Lozano via TKO in the 1st round. Santiago improves his record to 12-2-2 (4 KOs)
On November 22, 2019, a 23-year-old Alexandro Santiago (20-2-5, 10 KOs) and Roberto Sanchez Cantu met in the ring in a bantamweight bout.
Santiago came in to the fight on a 4-fight win streak with a 37% KO rate, and was fighting after a gap of 3 months and 27 days.
Alexandro Santiago stopped Roberto Sanchez Cantu via TKO in the 8th round. Santiago improves his record to 21-2-5 (11 KOs)
On May 29, 2021, a 25-year-old Alexandro Santiago (23-2-5, 12 KOs) and Juan Gabriel Medina met in the ring.
Santiago came in to the fight on a 7-fight win streak with a 40% KO rate, and was fighting after a gap of 5 months and 21 days.
Alexandro Santiago stopped Juan Gabriel Medina via KO in the 2nd round. Santiago improves his record to 24-2-5 (13 KOs)
On February 9, 2013, a 17-year-old Alexandro Santiago (1-0, 1 KO) and Jose Lopez met in the ring.
Santiago came in to the fight on a 1-fight win streak with a 100% KO rate, and was fighting after a gap of 1 month and 19 days.
Alexandro Santiago stopped Jose Lopez via TKO in the 1st round. Santiago improves his record to 2-0 (2 KOs)
On December 8, 2020, a 24-year-old Alexandro Santiago (22-2-5, 11 KOs) and Erick Gonzalez Hernandez met in the ring.
Santiago came in to the fight on a 6-fight win streak with a 37% KO rate, and was fighting after a gap of 2 months and 17 days.
Alexandro Santiago stopped Erick Gonzalez Hernandez via RTD in the 4th round. Santiago improves his record to 23-2-5 (12 KOs)