On March 2, 2024, a 31-year-old René Santiago (12-3, 9 KOs) got a shot at the light-flyweight WBO title held by 32-year-old fellow Puerto Rican boxer Jonathan González (27-3-1, 14 KOs).
Santiago came in to the fight on a 3-fight win streak with a 60% KO rate, and was fighting after a gap of 4 months and 4 days. González was on a 5-fight win streak with a 45% KO rate, and fighting after a layoff of 1 year, 4 months, and 1 day.
Jonathan González defeated Rene Santiago via unanimous decision and successfully defended his WBO light-flyweight title. González improves his record to 28-3-1, while Santiago adds a loss to his record at 12-4.
On April 8, 2022, a 29-year-old René Santiago (9-2, 7 KOs) and Yudel Reyes met in the ring in a strawweight bout.
Santiago came in to the fight on a 3-fight win streak with a 63% KO rate, and was fighting after a gap of 5 months and 1 day.
René Santiago lost to Yudel Reyes via unanimous decision in the 10-round strawweight fight, and adds a loss to his record at 9-3.
On December 7, 2018, a 26-year-old René Santiago (6-1, 5 KOs) and Geovani Garcia Barragan met in the ring.
Santiago came in to the fight on a 2-fight win streak with a 71% KO rate, and was fighting after a gap of 3 months and 12 days.
René Santiago lost to Geovani Garcia Barragan via unanimous decision in the 6-round fight, and adds a loss to his record at 6-2.
On January 30, 2016, a 23-year-old René Santiago (4-0, 3 KOs) and Waldemar Pagan met in the ring.
Santiago came in to the fight on a 4-fight win streak with a 75% KO rate, and was fighting after a gap of 5 months and 8 days.
René Santiago lost to Waldemar Pagan via unanimous decision in the 6-round fight, and adds a loss to his record at 4-1.