On January 28, 2017, Léo Santa Cruz and Carl Frampton met again in an immediate rematch.
Cruz came in to the fight on a 1-fight losing streak with a 52% KO rate, and was fighting after a gap of 5 months and 29 days. Frampton was on a 23-fight win streak with a 60% KO rate, and fighting after a layoff of 5 months and 29 days.
Léo Santa Cruz defeated Carl Frampton via majority decision in the rematch and wins the WBA (Super) title. Cruz improves his record to 33-1-1, while Frampton adds a loss to his record at 23-1.
On September 13, 2014, the 26-year-old WBC super-bantamweight world champion, Léo Santa Cruz (27-0-1, 15 KOs), faced Manuel Roman, in a title defense fight.
Cruz came in to the fight on a 26-fight win streak with a 53% KO rate, and was fighting after a gap of 6 months and 5 days.
Léo Santa Cruz made very easy work of Manuel Roman, stopping the challenger via KO in the 2nd. Cruz improves his record to 28-0-1 (16 KOs)
On August 24, 2013, a 25-year-old Léo Santa Cruz (24-0-1, 14 KOs) got a shot at the WBC super-bantamweight title held by Victor Terrazas.
Cruz came in to the fight on a 23-fight win streak with a 56% KO rate, and was fighting after a gap of 3 months and 20 days.
Léo Santa Cruz made easy work of Victor Terrazas, stopping the champion via TKO in the 3rd. Cruz improves his record to 25-0-1 (15 KOs)
On February 27, 2016, the 27-year-old WBA (Super) featherweight world champion, Léo Santa Cruz (31-0-1, 17 KOs), faced a 29-year-old Spanish boxer Kiko Martínez (35-6, 26 KOs), in a title defense fight.
Cruz came in to the fight on a 30-fight win streak with a 53% KO rate, and was fighting after a gap of 5 months and 29 days. Martínez was on a 3-fight win streak with a 63% KO rate, and fighting after a layoff of 2 months and 15 days.
Léo Santa Cruz stopped Kiko Martínez via TKO in the 5th round of the 12-round world-title fight, and successfully defended his WBA (Super) featherweight title. Cruz improves his record to 32-0-1 (18 KOs), while Martínez adds a loss to his record at 35-7.
On September 15, 2012, the 24-year-old IBF bantamweight world champion, Léo Santa Cruz (20-0-1, 11 KOs), faced Eric Morel, in a title defense fight.
Cruz came in to the fight on a 19-fight win streak with a 52% KO rate, and was fighting after a gap of 3 months and 13 days.
The challenger refused to continue the fight in the 5th round, and Léo Santa Cruz is crowned the new bantamweight world champion. Cruz improves his record to 21-0-1 (12 KOs)
On January 17, 2015, the 26-year-old WBC super-bantamweight world champion, Léo Santa Cruz (28-0-1, 16 KOs), faced a 25-year-old fellow Mexican boxer Jesus Ruiz (33-5-5, 22 KOs), in a title defense fight.
Cruz came in to the fight on a 27-fight win streak with a 55% KO rate, and was fighting after a gap of 4 months and 4 days. Ruiz was on a 5-fight win streak with a 51% KO rate, and fighting after a layoff of 2 months and 10 days.
Léo Santa Cruz stopped Jesus Ruiz via TKO in the 8th round of the 12-round world-title fight, and successfully defended his WBC super-bantamweight title. Cruz improves his record to 29-0-1 (17 KOs), while Ruiz adds a loss to his record at 33-6-5.
On October 14, 2017, the 29-year-old WBA (Super) featherweight world champion, Léo Santa Cruz (33-1-1, 18 KOs), faced Chris Avalos, in a title defense fight.
Cruz came in to the fight on a 1-fight win streak with a 51% KO rate, and was fighting after a gap of 8 months and 16 days.
Léo Santa Cruz stopped Chris Avalos via KO in the 8th round of the 12-round world-title fight, and successfully defended his WBA (Super) featherweight title. Cruz improves his record to 34-1-1 (19 KOs)
On June 9, 2018, Léo Santa Cruz and Abner Mares met again in a rematch.
Cruz came in to the fight on a 2-fight win streak with a 52% KO rate, and was fighting after a gap of 7 months and 26 days. Mares was on a 2-fight win streak with a 44% KO rate, and fighting after a layoff of 7 months and 26 days.
Léo Santa Cruz defeated Abner Mares via unanimous decision in the rematch and successfully defended his WBA (Super) featherweight title. Cruz improves his record to 35-1-1, while Mares adds a loss to his record at 31-3-1.
On November 10, 2012, the 24-year-old IBF bantamweight world champion, Léo Santa Cruz (21-0-1, 12 KOs), faced Victor Zaleta, in a title defense fight.
Cruz came in to the fight on a 20-fight win streak with a 54% KO rate, and was fighting after a gap of 1 month and 26 days.
Léo Santa Cruz stopped Victor Zaleta via TKO in the 9th round of the 12-round world-title fight, and successfully defended his IBF bantamweight title. Cruz improves his record to 22-0-1 (13 KOs)
On November 23, 2019, 31-year-old Léo Santa Cruz (36-1-1, 19 KOs) and 27-year-old Miguel Flores (24-2, 12 KOs) fought for the vacant WBA (Super) super-featherweight title.
Cruz came in to the fight on a 4-fight win streak with a 50% KO rate, and was fighting after a gap of 9 months and 7 days. Flores was on a 2-fight win streak with a 46% KO rate, and fighting after a layoff of 4 months and 25 days.
Léo Santa Cruz defeated Miguel Flores via unanimous decision . Cruz improves his record to 37-1-1, while Flores adds a loss to his record at 24-3.